Mataupu
Vasculitis o tamaʻi capillaries
Vasculitis o tamaʻi capillaries
O se vaega tele lea o vasculitis o le puipui o arterioles, venules poʻo capillaries, o le faʻataʻitaʻiga e matua fesuisuiaʻi e faʻatatau i le mama poʻo le systemic cutaneous vasculitis.
O le itu masani o le falemaʻi o le purpura (lanu violē e le mou atu pe a oomi) faʻafefeteina ma faʻaulu, aemaise lava i vae pito i lalo, faʻaleagaina pe a tu, lea e mafai ona tele ituaiga (petechial ma ecchymotic, necrotic, pustular...) poʻo le ola, faia se ituaiga mata violē (livedo reticularis) po'o mottling (livedo racemosa) i luga o vae. E mafai foi ona tatou matauina se mea na tupu a Raynaud (o nai tamatamailima e paʻepaʻe i le malulu).
Purpura ma livedo e mafai ona fesoʻotaʻi ma isi faʻamaʻi i luga o le paʻu (papules, nodules, necrotic lesions, bleeding bubbles), urticaria tumau e le mageso.
O le i ai o faʻaaliga i fafo atu o le paʻu o loʻo i ai se vaega o le kalave, e faʻaalia ai le i ai o le aʻafiaga vascular i totoga:
- tiga soʻoga,
- tiga o le manava, fe'ai uliuli, faaletonu femalagaiga,
- neuropathy peripheral
- edema o vae pito i lalo,
- maualuga toto maualuga,
- faigata manava, sela, tale toto...
O le fomaʻi e faʻatonuina suʻega e faʻatatau i le suʻeina o se mafuaʻaga ma faʻailoga o le ogaoga: suʻega toto ma le numera o le toto, suʻesuʻe mo le mumu, suʻega o le ate ma fatugaʻo, ma isi, suʻesuʻe mo le toto i totonu o le nofoa ma x-ray e tusa ai ma vala o le telefoni ( x-ray o le mama pe a fa'aletonu le manava, ma isi).
Vasculitis e mafua ona o faʻamaʻi:
- siama: streptococcus, gram-negative cocci (gonococcus ma le maningococcus)
- viral: hepatitis, mononucleosis faʻamaʻi, HIV, ma isi.
- parasite: malaria…
- fungal: Candida albicans…
Vasculitis e feso'ota'i ma fa'aletonu fa'ama'i
- Ituaiga II (mixed monoclonal) ma III (mixed polyclonal) cryoglobulinemia, e fesoʻotaʻi ma faʻamaʻi autoimmune, faʻamaʻi (aemaise lava le hepatitis C) poʻo le maʻi toto.
- Hypocomplementémie (Mac Duffie's urticarienne vascularite)
- Hyperglobulinémie (Waldenström's hyperglobulinémique viole)
- Connectivitis: lupus, Gougerot-Sjögren syndrome, fa'ama'i rūmatoid…
- Vasculitis o faʻamaʻi toto ma faʻamaʻi leaga
- Leukemia, lymphoma, myeloma, kanesa
- Vasculitis e feso'ota'i ma ANCA (anti-neutrophil cytoplasmic antibodies)
Micro Poly Angéite po'o MPA
Micropolyangiitis (MPA) o se angeitis necrotizing faʻapitoa o ona faʻailoga faʻapitoa e tutusa lelei ma le PAN.
O le MPA e fesoʻotaʻi ma le ANCA o le anti-myeloperoxidase (anti-MPO) ituaiga ma e masani ona faʻatupuina le faʻasolosolo vave o le glomerulonephritis ma le aʻafiaga o le pulmonary lea e le o iai i le PAN.
O le togafitiga o le MPA e pei o le PAN e amata ile corticosteroid therapy, o nisi taimi e tuʻufaʻatasia ma immunosuppressants (cyclophosphamide faʻapitoa)
Wegener's faamaʻi
O le granulomatosis a Wegener o se vasculitis e masani ona fa'ailogaina ile ENT po'o fa'ailoga manava (sinusitis, pneumopathy, ma isi) e tete'e i togafitiga fa'ama'i.
E masani lava, fa'asalalauina le ENT (pansinusitis fa'aleagaina), pulmonary (parenchymal nodules) ma le fatu (crescent pauci-immune necrotizing glomerulonephritis) e maua ai le ta'i tolu masani o le granulomatosis a Wegener.
O le paʻu-mucous membrane e aʻafia ai le tusa ma le 50% o tagata mamaʻi: purpura (lanu violē e le mou atu pe a oomiina) faʻafefeteina ma faʻaulufale, papules, nodules i lalo, maʻi paʻu, pustules, vesicles, hyperplastic gingivitis ...
O le ANCA o se su'esu'ega fa'ama'i ma su'esu'ega mo le granulomatosis a Wegener, fa'atasi ai ma le fa'afefeteina o le cytoplasmic fluorescence (c-ANCA), fa'ama'i mama ma le fa'aleleia atili o le perinuclear ma / po'o le mama o le perinuclear fluorescence (p-ANCA).
O le puleaina o le granulomatosis a Wegener, lea e mafai ona manatu i nisi taimi o se faʻalavelave faʻafuaseʻi, e tatau ona faia i totonu o se falemaʻi faʻapitoa, e ala i le tuʻufaʻatasia o le cortisone ma le cyclophosphamide oral.
Fa'ama'i Churg ma Strauss
O le Asthma o se fa'ata'ita'iga tele ma vave o lenei vasculitis, lea e muamua i le averesi i le 8 tausaga a'o le'i o'o i fa'ailoga muamua o vasculitis (neuropathy, sinus disorders, etc.) ma e fa'aauau pea mulimuli ane.
O su'ega o le toto e fa'aalia fa'apitoa ai le fa'atupula'ia manino o sela pa'epa'e eosinophilic polynuclear
Togafitiga ole ma'i Churg ma Strauss e amata ile togafitiga ole corticosteroid, o nisi taimi e tu'ufa'atasia ma immunosuppressants (aemaise ole cyclophosphamide)
O le manatu o le matou fomaʻi
O le purpura infiltrated (lanu violē, e fai si mafiafia fa'ailoga e le mou atu i le mamafa o tamatamai lima) o le fa'ailoga autu lea o le vasculitis. Ae paga lea, o lenei faʻailoga e le o iai i taimi uma ma o le fesuisuiai o faʻailoga faʻapitoa faʻapitoa e masani ona faigata ai suʻesuʻega mo fomaʻi. E faʻapea foʻi, e masani ona faigata ona maua se mafuaʻaga e togafitia ai le vasculitis vaʻa laiti, lea e sili atu le taua o le faʻataʻitaʻiga i le taimi nei pe a faʻatusatusa i vasculitis vaʻa feololo ma lapopoa: e tusa ma le afa o vasculitis vaʻa laiti. o va'a e leai se mafua'aga na maua i le taimi o su'esu'ega fa'aletino ma le leitio o lo'o faia e le foma'i e su'e ai se etiology. E masani ona matou talanoa e uiga i le "vasculitis allergy" poʻo le "vasculitis hypersensitivity" poʻo le "vasculitis paʻu o vaʻa laiti o le idiopathic caliber". Dr. Ludovic Rousseau, fomaʻi o toto |
Nofoaga Iloga
Vaega Su'esu'e Vasculitis Farani: www.vascularites.org
Dermatonet.com, 'upega tafaʻilagi luga o le paʻu, lauulu ma le lalelei e se fomaʻi fomaʻi
MedicineNet : http://www.medicinenet.com/vasculitis/article.htm